The cees dekker Diaries

The cees dekker Diaries

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‘The 2nd is nanopores, which is our oldest line of research and that has now triggered DNA sequencers based on nanopores. We pull individual DNA strands via a nanopore and will then browse from the nucleotide sequence. Pretty recently, we even managed to browse out only one protein for The 1st time employing This method. But this line of study is not only about developing applications, and also about true biological questions.

Human Rad51 filaments on double- and single-stranded DNA: correlating common and irregular forms with recombination operate.

Dynamics of initiation, termination and reinitiation of DNA translocation with the motor protein EcoR124I

A rhythmically pulsing leaf-spring DNA-origami nanoengine that drives a passive follower Mathias Centola

This yielded a breakthrough. Within just a few months, we were in the position to measure transportation via somebody single-walled carbon nanotube. Based upon minimal-temperature experiments by a superb PhD pupil in my team, Sander Tans (now a valued colleague and professor at Delft University of Know-how with an Energetic investigate lab at AMOLF in Amsterdam), we showed that carbon nanotubes were real quantum wires with pretty extended (micrometres) Digital coherence lengths — confirming theoretical predictions of metallic conduct.

Within the years next these discoveries, my investigate pursuits shifted to biophysics and nanobiology, and I became less linked to the event of nanotube electronics. The focus of many scientists in the sector also shifted to graphene (in which, funnily sufficient, the first graphene ribbons were being referred to as ‘nanotubes which can be Reduce open up alongside their length’) just after the discovery of the two-dimensional substance in 2004.

We form germs into types that deviate from their all-natural phenotype. Specifically, I'll demonstrate our capacity to form Reside E. coli bacteria into novel styles for instance rectangles, squares, triangles and circles.

Atomic drive microscopy shows that vaccinia topoisomerase IB generates filaments on DNA within a cooperative vogue

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But carbon nanotubes have remained a investigation subject of substantial interest to numerous. Indeed, the outlook on using carbon nanotubes to make simple products, in ceesdekker regions for example radio-frequency electronics, digital electronics and flexible electronics, continues to be vivid.

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Case in point (2) of bending configurations in 3D simulations of DNA rods on nanopores. A percentage of the membrane is proven in gray, the rim from the pore is highlighted in purple, along with a 3D rendering with the motion on the DNA rod is displayed.